Data Import
## Rows: 231 Columns: 170
## ── Column specification ────────────────────────────────────────────────────────
## Delimiter: ","
## chr (2): cGVHD_day, Source
## dbl (168): ID, Time_OS, cGVHD_time, Collection_Day, 4_TFH, 4_TH1, 4_TH17, 4_...
##
## ℹ Use `spec()` to retrieve the full column specification for this data.
## ℹ Specify the column types or set `show_col_types = FALSE` to quiet this message.
## # A tibble: 6 × 170
## ID Time_OS cGVHD_time cGVHD_day Collection_Day Source `4_TFH` `4_TH1`
## <dbl> <dbl> <dbl> <chr> <dbl> <chr> <dbl> <dbl>
## 1 50 663 NA <NA> 180 ПЕР.КРОВЬ 127. 14.1
## 2 69 503 203 <NA> 180 ПЕР.КРОВЬ 99.4 11.8
## 3 58 257 NA <NA> 180 ПЕР.КРОВЬ 91.9 31.6
## 4 2 434 134 <NA> 180 ПЕР.КРОВЬ 77.1 15.9
## 5 52 792 NA <NA> 180 ПЕР.КРОВЬ 76.5 30.6
## 6 42 363 NA <NA> 180 ПЕР.КРОВЬ 72.0 56.2
## # ℹ 162 more variables: `4_TH17` <dbl>, `4_Th17TO1` <dbl>, `4_TH2` <dbl>,
## # `4_TH22` <dbl>, `4+ (IM STAT)` <dbl>, `4+` <dbl>, `4+226+` <dbl>,
## # `4+39+` <dbl>, `4+DR+` <dbl>, `4+PD-1+` <dbl>, `4+PD-1+TIGIT-` <dbl>,
## # `4+PD-1+TIGIT+` <dbl>, `4+PD-1-TIGIT-` <dbl>, `4+PD-1-TIGIT+` <dbl>,
## # `4+TIGIT+` <dbl>, `4NV(CTAP2)` <dbl>, `4NV` <dbl>, `4NV_TH1` <dbl>,
## # `4NV_TH17` <dbl>, `4NV_Th17TO1` <dbl>, `4NV_TH2` <dbl>, `4NV_TH22` <dbl>,
## # `4NV+226+` <dbl>, `4NV+39+` <dbl>, `4NV+DR+` <dbl>, `4NV+PD1+` <dbl>, …
## Rows: 231
## Columns: 170
## $ ID <dbl> 50, 69, 58, 2, 52, 42, 44, 1, 31, 49, 34, 33, 8, 6…
## $ Time_OS <dbl> 663, 503, 257, 434, 792, 363, 391, 786, 469, 447, …
## $ cGVHD_time <dbl> NA, 203, NA, 134, NA, NA, NA, NA, NA, 186, NA, NA,…
## $ cGVHD_day <chr> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA…
## $ Collection_Day <dbl> 180, 180, 180, 180, 180, 180, 180, 180, 180, 180, …
## $ Source <chr> "ПЕР.КРОВЬ", "ПЕР.КРОВЬ", "ПЕР.КРОВЬ", "ПЕР.КРОВЬ"…
## $ `4_TFH` <dbl> 127.34533, 99.38984, 91.87249, 77.06436, 76.47210,…
## $ `4_TH1` <dbl> 14.062674, 11.781381, 31.623640, 15.915147, 30.627…
## $ `4_TH17` <dbl> 15.024225, 35.147095, 14.125735, 27.727585, 50.554…
## $ `4_Th17TO1` <dbl> 7.128995, 8.099699, 6.880244, 2.862568, 4.037329, …
## $ `4_TH2` <dbl> 22.889407, 18.418778, 34.494655, 18.439329, 47.335…
## $ `4_TH22` <dbl> 3.1100145, 13.5029558, 3.9582638, 9.2041168, 8.611…
## $ `4+ (IM STAT)` <dbl> 90.77828, 162.26784, 261.89949, 56.84151, 69.79759…
## $ `4+` <dbl> 94.49681, 179.88505, 282.24347, 71.90422, 87.06514…
## $ `4+226+` <dbl> 386.6356, 352.1949, 408.3863, 262.6972, 406.0821, …
## $ `4+39+` <dbl> 5.795184, 132.059823, 84.769777, 79.709945, 164.84…
## $ `4+DR+` <dbl> 199.30241, 154.37072, 104.50374, 56.59555, 186.485…
## $ `4+PD-1+` <dbl> 302.7878, 187.1699, 180.4774, 191.6250, 280.1443, …
## $ `4+PD-1+TIGIT-` <dbl> 119.50988, 76.57133, 42.66542, 76.63674, 144.95011…
## $ `4+PD-1+TIGIT+` <dbl> 183.27796, 110.59861, 137.81197, 114.98826, 135.19…
## $ `4+PD-1-TIGIT-` <dbl> 89.72713, 163.22605, 216.51858, 82.54746, 137.7361…
## $ `4+PD-1-TIGIT+` <dbl> 7.647398, 28.278619, 21.748989, 5.082110, 16.62370…
## $ `4+TIGIT+` <dbl> 190.92535, 138.87723, 159.56096, 120.07037, 151.81…
## $ `4NV(CTAP2)` <dbl> 31.761257, 84.172040, 184.628105, 32.643348, 50.02…
## $ `4NV` <dbl> 41.466861, 88.961870, 219.785571, 40.736265, 52.77…
## $ `4NV_TH1` <dbl> 0.323020835, 1.918622750, 18.644611690, 1.54194564…
## $ `4NV_TH17` <dbl> 2.6217272, 2.7949667, 1.5714137, 1.0700335, 5.2005…
## $ `4NV_Th17TO1` <dbl> 0.04507267, 0.71040896, 0.75597742, 0.10974702, 0.…
## $ `4NV_TH2` <dbl> 18.3070180, 4.9469354, 13.5056641, 11.2527278, 26.…
## $ `4NV_TH22` <dbl> 0.300484497, 0.337055348, 0.186870823, 0.005487351…
## $ `4NV+226+` <dbl> 30.203713, 73.796574, 182.456222, 31.181321, 42.10…
## $ `4NV+39+` <dbl> 0.266606529, 5.901336215, 6.533746279, 0.366427476…
## $ `4NV+DR+` <dbl> 7.7105415, 12.3602790, 18.9677731, 1.0293114, 4.07…
## $ `4NV+PD1+` <dbl> 3.64829987, 9.88424030, 16.76572568, 6.50178601, 3…
## $ `4NV+PD-1+TIGIT-` <dbl> 2.40647472, 5.33709147, 10.74478497, 5.17233557, 1…
## $ `4NV+PD-1+TIGIT+` <dbl> 1.241825148, 4.547148827, 6.020940708, 1.329450440…
## $ `4NV+PD-1-TIGIT-` <dbl> 27.102658, 71.161220, 162.969611, 26.043971, 41.00…
## $ `4NV+PD-1-TIGIT+` <dbl> 1.01029843, 3.12657970, 4.89276845, 0.09759124, 5.…
## $ `4NV+TIGIT+` <dbl> 2.2521236, 7.6737285, 10.9137092, 1.4270417, 7.078…
## $ `4EM` <dbl> 3.41049904, 20.88187518, 5.99685460, 1.70107882, 2…
## $ `4EM_TH1` <dbl> 1.62261629, 0.68448163, 1.01080127, 0.60726685, 10…
## $ `4EM_TH17` <dbl> 0.007512112, 0.067411070, 0.161388438, 0.005487351…
## $ `4EM_Th17TO1` <dbl> 0.03756056, 0.13482214, 1.06176604, 0.02012029, 0.…
## $ `4EM_TH2` <dbl> 0.105169574, 0.150378540, 0.186870823, 0.042069691…
## $ `4EM_TH22` <dbl> 0.007512112, 0.005185467, 0.033976513, 0.001829117…
## $ `4EM+226+` <dbl> 226.06129, 108.34827, 71.93757, 160.45841, 234.235…
## $ `4EM+39+` <dbl> 3.7465233, 59.5178633, 22.4126200, 59.9154956, 109…
## $ `4EM+DR+` <dbl> 128.63063, 61.86114, 38.00794, 45.81080, 133.40600…
## $ `4EM+PD1+` <dbl> 200.20046, 81.35745, 54.20657, 132.50680, 195.3734…
## $ `4EM+PD1+TIGIT-` <dbl> 83.51800, 33.42984, 13.60443, 51.80622, 107.60485,…
## $ `4EM+PD1+TIGIT+` <dbl> 116.68245, 47.92761, 40.60214, 80.70059, 87.76860,…
## $ `4EM+PD1-TIGIT-` <dbl> 30.407176, 25.868962, 15.752181, 35.722076, 45.611…
## $ `4EM+PD1-TIGIT+` <dbl> 2.6871132, 8.8685998, 4.2231047, 2.8577660, 3.8524…
## $ `4EM+TIGIT+` <dbl> 119.36957, 56.79621, 44.82524, 83.55835, 91.62102,…
## $ `4EMTM` <dbl> 233.29474, 116.09502, 74.18185, 171.08665, 244.836…
## $ `4CM(CTAP2)` <dbl> 102.117317, 68.306805, 107.447850, 56.335923, 90.9…
## $ `4CM` <dbl> 139.84548, 123.19114, 146.46425, 102.30434, 100.90…
## $ `4CM_TH1` <dbl> 0.31550872, 2.08974316, 7.15205606, 3.72591135, 0.…
## $ `4CM_TH17` <dbl> 6.625683, 13.611851, 9.453965, 15.079241, 20.37863…
## $ `4CM_Th17TO1` <dbl> 0.2178513, 2.2712345, 2.2934146, 0.5816592, 0.1298…
## $ `4CM_TH2` <dbl> 2.764457, 6.207004, 18.219905, 4.680710, 8.972470,…
## $ `4CM_TH22` <dbl> 0.65355378, 3.10609467, 1.09574255, 0.51764011, 0.…
## $ `4CM+226+` <dbl> 99.584555, 66.275524, 105.794806, 54.043449, 85.56…
## $ `4CM+39+` <dbl> 0.4139417, 35.9589857, 41.6398124, 15.4415116, 38.…
## $ `4CM+DR+` <dbl> 40.6785436, 24.7869397, 24.2526870, 5.7468349, 24.…
## $ `4CM+PD1+` <dbl> 74.6498281, 44.9935398, 75.0566366, 41.6696170, 53…
## $ `4CM+PD1+TIGIT-` <dbl> 26.1274398, 10.9861771, 12.2711357, 16.1762079, 19…
## $ `4CM+PD1+TIGIT+` <dbl> 48.5223883, 34.0073627, 62.7855009, 25.4934091, 34…
## $ `4CM+PD1-TIGIT-` <dbl> 24.997870, 16.688368, 25.694576, 13.598326, 32.519…
## $ `4CM+PD1-TIGIT+` <dbl> 2.4696184, 6.6248971, 6.6966375, 1.0679796, 4.6588…
## $ `4CM+TIGIT+` <dbl> 50.9920067, 40.6322598, 69.4821384, 26.5613886, 39…
## $ `4TM_TH1` <dbl> 10.171400, 4.101704, 3.355181, 7.951172, 16.826910…
## $ `4TM_TH17` <dbl> 5.3260877, 16.9098075, 2.7690858, 11.0789617, 22.8…
## $ `4TM_Th17TO1` <dbl> 6.392808, 3.370553, 2.284921, 1.968130, 3.241157, …
## $ `4TM_TH2` <dbl> 1.3146197, 5.8958759, 2.2934146, 2.1437251, 7.3236…
## $ `4TM_TH22` <dbl> 1.9231008, 8.6804716, 2.4972737, 7.9749502, 7.3518…
## $ `4TREG(CTAP2)` <dbl> 98.62351, 180.60935, 296.08196, 69.49479, 106.7151…
## $ `4TREG` <dbl> 1.2871261, 2.5038358, 9.5152491, 4.1881298, 2.9542…
## $ `4TREG_TH1` <dbl> 0.20806853, 0.34068011, 0.60385775, 0.14889903, 0.…
## $ `4TREG_TH17` <dbl> 1.9627798, 8.2477556, 11.2160986, 3.7187533, 12.56…
## $ `4TREG_Th17TO1` <dbl> 0.131776734, 0.335185271, 0.178920814, 0.046530948…
## $ `4TREG_TH2` <dbl> 3.5441006, 2.4177298, 5.1216083, 2.4661402, 3.2284…
## $ `4TREG_TH22` <dbl> 0.5479138, 6.2970872, 12.1777979, 3.8899872, 3.786…
## $ `4TE(CTAP2)` <dbl> 26.934275, 106.794935, 44.776976, 14.226225, 46.40…
## $ `4TE` <dbl> 0.70613857, 42.61935239, 1.67334328, 0.12803819, 3…
## $ `4TE_TH1` <dbl> 0.19531492, 1.27562486, 0.16138844, 0.06950645, 1.…
## $ `4TE_TH17` <dbl> 0.000000000, 0.041483735, 0.000000000, 0.000000000…
## $ `4TE_Th17TO1` <dbl> 0.022536337, 0.399280951, 0.195364952, 0.001829117…
## $ `4TE_TH2` <dbl> 0.037560562, 0.290386146, 0.000000000, 0.000000000…
## $ `4TE_TH22` <dbl> 0.000000000, 0.005185467, 0.000000000, 0.000000000…
## $ `4TE+226+` <dbl> 25.053998, 101.252060, 41.120974, 12.224683, 42.29…
## $ `4TE+39+` <dbl> 1.2348092, 29.5398719, 12.8804694, 2.5797231, 14.2…
## $ `4TE+DR+` <dbl> 19.567516, 55.169860, 22.201465, 3.264703, 24.9202…
## $ `4TE+PD-1+` <dbl> 20.374352, 50.071742, 31.437998, 6.910564, 28.3869…
## $ `4TE+PD-1+TIGIT-` <dbl> 6.286301, 27.282893, 5.490036, 2.855925, 16.391420…
## $ `4TE+PD-1+TIGIT+` <dbl> 14.088050, 22.788850, 25.947962, 4.054640, 11.9955…
## $ `4TE+PD-1-TIGIT-` <dbl> 5.479466, 47.449664, 8.446209, 6.308445, 15.444750…
## $ `4TE+PD-1-TIGIT+` <dbl> 1.0804580, 9.2735283, 4.8927685, 1.0072152, 2.5726…
## $ `4TE+TIGIT+` <dbl> 15.168508, 32.062378, 30.840730, 5.061855, 14.5682…
## $ `4ТМ` <dbl> 193.45192, 85.67428, 55.09292, 125.27988, 245.5317…
## $ `8+ (IM STAT)` <dbl> 1019.30819, 265.97665, 140.28147, 867.29435, 2200.…
## $ `8+` <dbl> 962.34410, 242.27120, 105.70795, 582.72812, 2078.5…
## $ `8+226+` <dbl> 1194.6002, 484.9047, 298.7185, 729.3970, 2432.9600…
## $ `8+39+` <dbl> 5.747305, 92.302092, 30.795167, 205.715840, 345.50…
## $ `8+DR+` <dbl> 1287.79608, 326.33398, 135.99260, 791.49995, 2069.…
## $ `8+PD-1+` <dbl> 970.31941, 138.45314, 101.97656, 900.43942, 1155.2…
## $ `8+PD-1+TIGIT-` <dbl> 77.640580, 27.079420, 17.178013, 138.856503, 211.6…
## $ `8+PD-1+TIGIT+` <dbl> 892.67883, 111.37372, 84.79855, 761.58292, 943.601…
## $ `8+PD-1-TIGIT-` <dbl> 84.81872, 213.46493, 137.54041, 89.69943, 351.8652…
## $ `8+PD-1-TIGIT+` <dbl> 360.85724, 175.20728, 124.73743, 244.00916, 1178.0…
## $ `8+TIGIT+` <dbl> 1253.5361, 286.5810, 209.5360, 1005.5921, 2121.675…
## $ `8EMTM` <dbl> 505.443134, 29.563471, 18.376895, 354.466540, 181.…
## $ `8EMTM+226+` <dbl> 358.866864, 23.925330, 13.286119, 200.812451, 164.…
## $ `8EMTM+39+` <dbl> 1.2070141, 9.4214157, 3.8918936, 60.7161932, 57.66…
## $ `8EMTM+DR+` <dbl> 478.944779, 22.724161, 13.948189, 284.785966, 151.…
## $ `8EMTM+PD-1+` <dbl> 448.201891, 13.531539, 15.218646, 271.402973, 114.…
## $ `8EMTM+PD-1+TIGIT-` <dbl> 37.5932923, 1.6832712, 0.7604849, 33.8429200, 26.0…
## $ `8EMTM+PD-1+TIGIT+` <dbl> 410.608599, 11.848268, 14.458161, 237.560053, 88.2…
## $ `8EMTM+PD-1-TIGIT-` <dbl> 20.3833501, 7.5093504, 0.7783787, 13.5737249, 21.2…
## $ `8EMTM+PD-1-TIGIT+` <dbl> 36.8578930, 8.5225816, 2.3798705, 69.4898420, 45.7…
## $ `8EMTM+TIGIT+` <dbl> 447.466492, 20.370849, 16.838031, 307.049895, 134.…
## $ `8NV(CTAP2)` <dbl> 17.313857, 30.454134, 93.736480, 29.408413, 26.488…
## $ `8NV` <dbl> 19.845371, 32.065751, 117.968132, 24.398920, 12.41…
## $ `8NV+226+` <dbl> 16.634412, 26.621832, 91.642910, 27.926270, 23.856…
## $ `8NV+39+` <dbl> 0.23181065, 3.26848768, 1.63727936, 4.27159082, 3.…
## $ `8NV+DR+` <dbl> 6.8184304, 7.7953431, 8.5890065, 10.5180473, 14.18…
## $ `8NV+PD-1+` <dbl> 5.6353968, 6.6677149, 7.0054084, 22.0414086, 12.97…
## $ `8NV+PD-1+TIGIT-` <dbl> 0.71941236, 3.44825450, 5.47549162, 5.90472926, 1.…
## $ `8NV+PD-1+TIGIT+` <dbl> 4.9159844, 3.2194604, 1.5299168, 16.1366794, 11.59…
## $ `8NV+PD-1-TIGIT-` <dbl> 8.3132094, 22.4381679, 83.5459816, 7.1484576, 5.66…
## $ `8NV+PD-1-TIGIT+` <dbl> 3.36525113, 1.34825117, 3.18508990, 0.21854651, 7.…
## $ `8NV+TIGIT+` <dbl> 8.2812356, 4.5677115, 4.7150067, 16.3552259, 19.44…
## $ `8TREG` <dbl> 971.97659, 240.49887, 106.93989, 491.36808, 1904.1…
## $ `8EM` <dbl> 260.027365, 33.397354, 17.007042, 136.430774, 283.…
## $ `8CM(CTAP2)` <dbl> 29.37600453, 2.45953698, 6.45070173, 11.42004838, …
## $ `8CM` <dbl> 54.1192204, 9.6872520, 11.9292252, 17.6698463, 4.6…
## $ `8CM+226+` <dbl> 21.15871673, 2.24708528, 5.05498818, 9.50081269, 5…
## $ `8CM+39+` <dbl> 0.15986941, 1.25019654, 2.59459570, 2.78944814, 3.…
## $ `8CM+DR+` <dbl> 27.98514064, 1.65875750, 4.39291893, 9.54452199, 4…
## $ `8CM+PD-1+` <dbl> 26.13864893, 1.47899067, 4.58975033, 10.39486658, …
## $ `8CM+PD-1+TIGIT-` <dbl> 1.902446008, 0.204280480, 0.196831398, 0.925842475…
## $ `8CM+PD-1+TIGIT+` <dbl> 24.23620292, 1.27471019, 4.39291893, 9.46902411, 3…
## $ `8CM+PD-1-TIGIT-` <dbl> 1.43083124, 0.58015656, 0.65312237, 0.34570084, 0.…
## $ `8CM+PD-1-TIGIT+` <dbl> 1.80652436, 0.40038974, 1.20782903, 0.67948096, 1.…
## $ `8CM+TIGIT+` <dbl> 26.04272728, 1.67509993, 5.60074797, 10.14850506, …
## $ `8TE(CTAP2)` <dbl> 825.56565, 463.11202, 236.68081, 835.54701, 2454.1…
## $ `8TE` <dbl> 584.32855, 366.84708, 138.83820, 488.42954, 1984.1…
## $ `8TE+226+` <dbl> 768.94789, 430.77850, 180.94174, 487.81964, 2224.9…
## $ `8TE+39+` <dbl> 3.804892, 77.454987, 21.302525, 137.032633, 275.14…
## $ `8TE+DR+` <dbl> 740.85884, 294.06584, 107.33574, 484.73615, 1885.9…
## $ `8TE+PD-1+` <dbl> 458.96910, 116.03948, 73.02445, 593.27429, 1012.86…
## $ `8TE+PD-1+TIGIT-` <dbl> 35.778774, 21.563847, 10.333648, 98.210827, 182.71…
## $ `8TE+PD-1+TIGIT+` <dbl> 423.19032, 94.47564, 62.69080, 495.06347, 830.1428…
## $ `8TE+PD-1-TIGIT-` <dbl> 52.07746, 181.87500, 47.51689, 68.44082, 322.49608…
## $ `8TE+PD-1-TIGIT+` <dbl> 314.51909, 165.19754, 116.13947, 173.83189, 1118.7…
## $ `8TE+TIGIT+` <dbl> 737.70941, 259.67317, 178.83027, 668.89536, 1948.9…
## $ `8ТМ` <dbl> 308.588888, 15.720485, 17.031338, 171.952985, 115.…
## $ TREG_CM <dbl> 1.66979879, 1.68609606, 7.77051266, 1.74927689, 2.…
## $ TREG_EMTM <dbl> 13.239119, 14.311902, 40.765026, 30.665745, 33.896…
## $ TREG_NV <dbl> 2.9396878, 2.7482038, 10.5818938, 0.9225134, 1.428…
## $ TREG_TE <dbl> 3.5921722, 14.5309617, 18.4549676, 3.1707945, 5.60…
## $ `TREG+226+` <dbl> 18.19940, 23.95053, 72.08840, 27.57965, 27.92239, …
## $ `TREG+226+TIGIT-` <dbl> 2.5678418, 3.5514228, 5.5383002, 3.1800013, 4.2950…
## $ `TREG+226+TIGIT+` <dbl> 15.631562, 20.399107, 66.550097, 24.399651, 23.627…
## $ `TREG+226-TIGIT-` <dbl> 1.4172242, 1.5865235, 2.2020475, 1.5467290, 1.7224…
## $ `TREG+226-TIGIT+` <dbl> 2.792353, 7.514412, 4.669547, 7.567924, 14.108016,…
## $ `TREG+39+` <dbl> 7.051041, 27.422295, 61.971045, 32.287969, 30.1619…
## $ `TREG+DR+` <dbl> 16.22090, 24.78030, 43.73327, 26.48958, 33.89167, …
## $ `TREG+PD-1+` <dbl> 13.653061, 11.351277, 35.262924, 24.325997, 18.100…
## $ `TREG+TIGIT+` <dbl> 18.42391, 27.91352, 71.21964, 31.96757, 37.73533, …
